EYA1 anticorps

N° du produit ABIN7114028

Détail du produit anti-EYA1 anticorps

Antigène: EYA1 (Eyes Absent Homolog 1 (EYA1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EYA1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: eyes absent homolog 1(Drosophila)

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur EYA1

Antigène: EYA1 (Eyes Absent Homolog 1 (EYA1))

Autre désignation: EYA1 (EYA1 Produits)

Synonymes: anticorps EYA1, anticorps bop, anticorps bor, anticorps XEya1, anticorps wu:fc13c10, anticorps zgc:100770, anticorps BOP, anticorps BOR, anticorps BOS1, anticorps EYA transcriptional coactivator and phosphatase 1, anticorps EYA transcriptional coactivator and phosphatase 1 L homeolog, anticorps EYA1, anticorps eya1, anticorps Eya1, anticorps eya1.L

Sujet: Synonyms: Background:Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5(By similarity). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX(H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress(PubMed:19234442). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis(By similarity). Has also phosphatase activity with proteins phosphorylated on Ser and Thr residues(in vitro)(By similarity). Required for normal embryonic development of the craniofacial and trunk skeleton, kidneys and ears(By similarity). Together with SIX1, it plays an important role in hypaxial muscle development, in this it is functionally redundant with EYA2(By similarity).

Poids moléculaire: 60 kDa ,50 kDa

ID gène: 2138

UniProt: Q99502

Pathways: Sensory Perception of Sound, Positive Regulation of Response to DNA Damage Stimulus