BRCA1-A Complex Subunit Abraxas 1 (ABRAXAS1) anticorps

N° du produit ABIN7114081

Cet anticorps Lapin Polyclonal détecte spécifiquement dans WB, IHC, ELISA et IF. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour BRCA1-A Complex Subunit Abraxas 1 (ABRAXAS1) anticorps (ABIN7114081)

Antigène: BRCA1-A Complex Subunit Abraxas 1 (ABRAXAS1)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Détail du produit

Fonction: ABRAXAS1 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: family with sequence similarity 175, member A

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2400, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détail du antigène

Antigène: BRCA1-A Complex Subunit Abraxas 1 (ABRAXAS1)

Autre désignation: ABRAXAS1

Sujet:

Synonyms: BRCA1-A complex subunit Abraxas 1|Coiled-coil domain-containing protein 98|Protein FAM175A|ABRAXAS1|ABRA1|CCDC98|FAM175A

Background: Involved in DNA damage response and double-strand break(DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.

Poids moléculaire: 46 kDa

ID gène: 84142

UniProt: Q6UWZ7