Glutathione Peroxidase 2 anticorps

N° du produit ABIN7114637

L’anticorps Lapin Polyclonal anti-Glutathione Peroxidase 2 a été validé pour ELISA, WB et IHC. Il convient pour détecter Glutathione Peroxidase 2 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Glutathione Peroxidase 2 anticorps (ABIN7114637)

Antigène: Glutathione Peroxidase 2 (GPX2)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Glutathione Peroxidase 2 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-Glutathione Peroxidase 2 anticorps

Fonction: GPX2 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: Glutathione peroxidase 2

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IHC: 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur Glutathione Peroxidase 2

Antigène: Glutathione Peroxidase 2 (GPX2)

Autre désignation: GPX2

Sujet:

Synonyms: Glutathione peroxidase 2 (GPx-2, GSHPx-2)|Gastrointestinal glutathione peroxidase|Glutathione peroxidase-gastrointestinal (GPx-GI, GSHPx-GI)|Glutathione peroxidase-related protein 2 (GPRP-2)|Phospholipid hydroperoxide glutathione peroxidase GPX2|GPX2

Background: The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is predominantly expressed in the gastrointestinal tract (also in liver in human), is localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. Overexpression of this gene is associated with increased differentiation and proliferation in colorectal cancer. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene.

Poids moléculaire: 21 kDa

UniProt: P18283

Pathways: Thyroid Hormone Synthesis