GRB7 anticorps

N° du produit ABIN7114786

Cet anticorps Lapin Polyclonal détecte spécifiquement GRB7 dans WB, ELISA et IP. Il présente une réactivité avec des échantillons de Humain et Souris.

Aperçu rapide pour GRB7 anticorps (ABIN7114786)

Antigène: GRB7 (Growth Factor Receptor-Bound Protein 7 (GRB7))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GRB7 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Détail du produit anti-GRB7 anticorps

Fonction: GRB7 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: growth factor receptor-bound protein 7

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IP: 1:200-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur GRB7

Antigène: GRB7 (Growth Factor Receptor-Bound Protein 7 (GRB7))

Autre désignation: GRB7

Sujet:

Synonyms: Growth factor receptor-bound protein 7|B47|Epidermal growth factor receptor GRB-7|GRB7 adapter protein|GRB7

Background: Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress(By similarity).

Poids moléculaire: 60-70 kDa

ID gène: 2886

UniProt: Q14451

Pathways: EGFR Signaling Pathway, Ribonucleoprotein Complex Subunit Organization