HEY1 anticorps

N° du produit ABIN7114852

Cet anticorps Lapin Polyclonal détecte spécifiquement HEY1 dans WB, ELISA, IHC et IP. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour HEY1 anticorps (ABIN7114852)

Antigène: HEY1 (Ha-Ry/enhancer-of-Split Related with YRPW Motif 1 (HEY1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HEY1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Détail du produit anti-HEY1 anticorps

Fonction: HEY1 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: hairy/enhancer-of-split related with YRPW motif 1

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:5000, IP: 1:200-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur HEY1

Antigène: HEY1 (Ha-Ry/enhancer-of-Split Related with YRPW Motif 1 (HEY1))

Autre désignation: HEY1

Sujet:

Synonyms: Hairy/enhancer-of-split related with YRPW motif protein 1|Cardiovascular helix-loop-helix factor 2 (CHF-2)|Class B basic helix-loop-helix protein 31 (bHLHb31)|HES-related repressor protein 1|Hairy and enhancer of split-related protein 1 (HESR-1)|Hairy-related transcription factor 1 (HRT-1, hHRT1)|HEY1|BHLHB31|CHF2|HERP2|HESR1|HRT1

Background: Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'(PubMed:11095750). Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3(PubMed:15485867). Involved in the regulation of liver cancer cells self-renewal(PubMed:25985737).

Poids moléculaire: 33 kDa

ID gène: 23462

UniProt: Q9Y5J3

Pathways: Tube Formation