HPSE anticorps

N° du produit ABIN7114948

Cet anticorps Lapin Polyclonal détecte spécifiquement HPSE dans WB, IHC et ELISA. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour HPSE anticorps (ABIN7114948)

Antigène: HPSE (Heparanase (HPSE))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HPSE est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Détail du produit anti-HPSE anticorps

Fonction: HPSE antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: heparanase

Isotype: IgG

Information d'application

Indications d'application: WB: 1:200-1:1000, IHC: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur HPSE

Antigène: HPSE (Heparanase (HPSE))

Autre désignation: HPSE

Sujet:

Synonyms: Heparanase|Endo-glucoronidase|Heparanase-1 (Hpa1)|Heparanase 8 kDa subunit|Heparanase 50 kDa subunit|HPSE|HEP|HPA|HPA1|HPR1|HPSE1|HSE1

Background: Endoglycosidase that cleaves heparan sulfate proteoglycans(HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix(ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans, and increases endothelial invasion and angiogenesis in myelomas. Acts as procoagulant by increasing the generation of activation factor X in the presence of tissue factor and activation factor VII. Increases cell adhesion to the extacellular matrix(ECM), independent of its enzymatic activity. Induces AKT1/PKB phosphorylation via lipid rafts increasing cell mobility and invasion. Heparin increases this AKT1/PKB activation. Regulates osteogenesis. Enhances angiogenesis through up-regulation of SRC-mediated activation of VEGF. Implicated in hair follicle inner root sheath differentiation and hair homeostasis.

Poids moléculaire: 60 kDa

ID gène: 10855

UniProt: Q9Y251

Pathways: Glycosaminoglycan Metabolic Process