HTRA1 anticorps

N° du produit ABIN7115116

Cet anticorps Lapin Polyclonal détecte spécifiquement HTRA1 dans WB, IHC, ELISA, IP et IF. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour HTRA1 anticorps (ABIN7115116)

Antigène: HTRA1 (HtrA Serine Peptidase 1 (HTRA1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HTRA1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP), Immunofluorescence (IF)

Détail du produit anti-HTRA1 anticorps

Fonction: HTRA1 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: HtrA serine peptidase 1

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur HTRA1

Antigène: HTRA1 (HtrA Serine Peptidase 1 (HTRA1))

Autre désignation: HTRA1

Sujet:

Synonyms: Serine protease HTRA1|High-temperature requirement A serine peptidase 1|L56|Serine protease 11|HTRA1|HTRA|PRSS11

Background: Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors(IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.

Poids moléculaire: 35 kDa, 50kD, 42 kDa

ID gène: 5654

UniProt: Q92743

Pathways: Growth Factor Binding