IMPA1 anticorps

N° du produit ABIN7115270

L’anticorps Lapin Polyclonal anti-IMPA1 a été validé pour WB, IHC, ELISA et IF. Il convient pour détecter IMPA1 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour IMPA1 anticorps (ABIN7115270)

Antigène: IMPA1 (Inositol(myo)-1(or 4)-Monophosphatase 1 (IMPA1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IMPA1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Détail du produit anti-IMPA1 anticorps

Fonction: IMPA1 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: inositol(myo)-1(or 4)-monophosphatase 1

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:10 - 1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur IMPA1

Antigène: IMPA1 (Inositol(myo)-1(or 4)-Monophosphatase 1 (IMPA1))

Autre désignation: IMPA1

Sujet:

Synonyms: Inositol monophosphatase 1 (IMP 1, IMPase 1)|D-galactose 1-phosphate phosphatase|Inositol-1(or 4)-monophosphatase 1|Lithium-sensitive myo-inositol monophosphatase A1|IMPA1|IMPA

Background: This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1, 4, 5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1, 3-diphosphate, myo-inositol-1, 4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti- manic and anti- depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13.

Poids moléculaire: 30 kDa

ID gène: 3612

UniProt: P29218