ITGB1BP1 anticorps

N° du produit ABIN7115324

L’anticorps Lapin Polyclonal anti-ITGB1BP1 a été validé pour WB, ELISA, IHC et IF. Il convient pour détecter ITGB1BP1 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour ITGB1BP1 anticorps (ABIN7115324)

Antigène: ITGB1BP1 (Integrin beta 1 Binding Protein 1 (ITGB1BP1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ITGB1BP1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-ITGB1BP1 anticorps

Fonction: ITGB1BP1 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: integrin beta 1 binding protein 1

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur ITGB1BP1

Antigène: ITGB1BP1 (Integrin beta 1 Binding Protein 1 (ITGB1BP1))

Autre désignation: ITGB1BP1

Sujet:

Synonyms: Integrin beta-1-binding protein 1|Integrin cytoplasmic domain-associated protein 1 (ICAP-1)|ITGB1BP1|ICAP1

Background: Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1(heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis. Stimulates cellular proliferation in a fibronectin-dependent manner. Involved in the regulation of beta-1 integrin-containing focal adhesion(FA) site dynamics by controlling its assembly rate during cell adhesion, inhibits beta-1 integrin clustering within FA by directly competing with talin TLN1, and hence stimulates osteoblast spreading and migration in a fibronectin-and/or collagen-dependent manner. Acts as a guanine nucleotide dissociation inhibitor(GDI) by regulating Rho family GTPases during integrin-mediated cell matrix adhesion, reduces the level of active GTP-bound form of both CDC42 and RAC1 GTPases upon cell adhesion to fibronectin. Stimulates the release of active CDC42 from the membranes to maintain it in an inactive cytoplasmic pool. Participates in the translocation of the Rho-associated protein kinase ROCK1 to membrane ruffles at cell leading edges of the cell membrane, leading to an increase of myoblast cell migration on laminin. Plays a role in bone mineralization at a late stage of osteoblast differentiation, modulates the dynamic formation of focal adhesions into fibrillar adhesions, which are adhesive structures responsible for fibronectin deposition and fibrillogenesis. Plays a role in blood vessel development, acts as a negative regulator of angiogenesis by attenuating endothelial cell proliferation and migration, lumen formation and sprouting angiogenesis by promoting AKT phosphorylation and inhibiting ERK1/2 phosphorylation through activation of the Notch signaling pathway. Promotes transcriptional activity of the MYC promoter.

Poids moléculaire: 22 kDa

ID gène: 9270

UniProt: O14713

Pathways: Tube Formation