KPNA5 anticorps

N° du produit ABIN7115574

Cet anticorps anti-KPNA5 est un anticorps Lapin Polyclonal détectant KPNA5 dans WB et ELISA. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour KPNA5 anticorps (ABIN7115574)

Antigène: KPNA5 (Karyopherin alpha 5 (Importin alpha 6) (KPNA5))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KPNA5 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-KPNA5 anticorps

Fonction: KPNA5 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: karyopherin alpha 5(importin alpha 6)

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur KPNA5

Antigène: KPNA5 (Karyopherin alpha 5 (Importin alpha 6) (KPNA5))

Autre désignation: KPNA5

Sujet:

Synonyms: Importin subunit alpha-6|Karyopherin subunit alpha-5|KPNA5

Background: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex(NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and-beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non-classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.

Poids moléculaire: 60 kDa

ID gène: 3841

UniProt: O15131

Pathways: Protein targeting to Nucleus