Laminin beta 1 anticorps

N° du produit ABIN7115764

Cet anticorps Lapin Polyclonal détecte spécifiquement Laminin beta 1 dans WB, IHC et ELISA. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour Laminin beta 1 anticorps (ABIN7115764)

Antigène: Laminin beta 1 (LAMB1) (Laminin, beta 1 (LAMB1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Laminin beta 1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Détail du produit anti-Laminin beta 1 anticorps

Fonction: LAMB1 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: laminin, beta 1

Isotype: IgG

Information d'application

Indications d'application: WB: 1:1000 - 1:4000, IHC: 1:100 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur Laminin beta 1

Antigène: Laminin beta 1 (LAMB1) (Laminin, beta 1 (LAMB1))

Autre désignation: LAMB1

Sujet:

Synonyms: Laminin subunit beta-1|Laminin B1 chain|Laminin-1 subunit beta|Laminin-10 subunit beta|Laminin-12 subunit beta|Laminin-2 subunit beta|Laminin-6 subunit beta|Laminin-8 subunit beta|LAMB1

Background: Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct domains which it shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis.

Poids moléculaire: 198 kDa

ID gène: 3912

UniProt: P07942