MARK4 anticorps

N° du produit ABIN7116062

L’anticorps Lapin Polyclonal anti-MARK4 a été validé pour ELISA et IHC. Il convient pour détecter MARK4 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour MARK4 anticorps (ABIN7116062)

Antigène: MARK4 (MAP/microtubule Affinity-Regulating Kinase 4 (MARK4))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MARK4 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Détail du produit anti-MARK4 anticorps

Fonction: MARK4 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: MAP/microtubule affinity-regulating kinase 4

Isotype: IgG

Information d'application

Indications d'application: IHC: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur MARK4

Antigène: MARK4 (MAP/microtubule Affinity-Regulating Kinase 4 (MARK4))

Autre désignation: MARK4

Sujet:

Synonyms: MAP/microtubule affinity-regulating kinase 4|MAP/microtubule affinity-regulating kinase-like 1|MARK4|KIAA1860|MARKL1

Background: Serine/threonine-protein kinase(PubMed:15009667, PubMed:14594945, PubMed:23666762, PubMed:23184942). Phosphorylates the microtubule-associated protein MAPT(PubMed:14594945, PubMed:23666762). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4(PubMed:14594945). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles(PubMed:14594945, PubMed:25123532). Required for the initiation of axoneme extension during cilium assembly(PubMed:23400999). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro(PubMed:23400999). Plays a role in cell cycle progression, specifically in the G1/S checkpoint(PubMed:25123532). Reduces neuronal cell survival(PubMed:15009667). Plays a role in energy homeostasis by regulating satiety and metabolic rate(By similarity). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway(By similarity). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation(PubMed:23184942).

ID gène: 57787

UniProt: Q96L34