MTF2 anticorps

N° du produit ABIN7116220

Cet anticorps Lapin Polyclonal détecte spécifiquement MTF2 dans WB, ELISA, IF, IHC et IP. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour MTF2 anticorps (ABIN7116220)

Antigène: MTF2 (Metal Response Element Binding Transcription Factor 2 (MTF2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MTF2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Détail du produit anti-MTF2 anticorps

Fonction: MTF2 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: metal response element binding transcription factor 2

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:1000, IP: 1:200-1:1000, IHC: 1:20-1:200, IF: 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur MTF2

Antigène: MTF2 (Metal Response Element Binding Transcription Factor 2 (MTF2))

Autre désignation: MTF2

Sujet:

Synonyms: Metal-response element-binding transcription factor 2|Metal regulatory transcription factor 2|Metal-response element DNA-binding protein M96|Polycomb-like protein 2 (hPCl2)|MTF2|PCL2

Background: Polycomb group(PcG) that specifically binds histone H3 trimethylated at 'Lys-36'(H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element(MRE) of MT1A gene promoter(By similarity).

Poids moléculaire: 60-61 kDa

ID gène: 22823

UniProt: Q9Y483

Pathways: Stem Cell Maintenance