MTF2 anticorps

N° du produit ABIN7116220

Détail du produit anti-MTF2 anticorps

Antigène: MTF2 (Metal Response Element Binding Transcription Factor 2 (MTF2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MTF2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: metal response element binding transcription factor 2

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:1000, IP: 1:200-1:1000, IHC: 1:20-1:200, IF: 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur MTF2

Antigène: MTF2 (Metal Response Element Binding Transcription Factor 2 (MTF2))

Autre désignation: MTF2 (MTF2 Produits)

Synonymes: anticorps mtf2a, anticorps xpcl2, anticorps MGC132044, anticorps m96, anticorps pcl2, anticorps Xpcl2, anticorps wu:cegs2813, anticorps zgc:136399, anticorps M96, anticorps PCL2, anticorps RP5-976O13.1, anticorps TDRD19A, anticorps dJ976O13.2, anticorps 9230112N11Rik, anticorps AA537621, anticorps C76717, anticorps Pcl2, anticorps RGD1304727, anticorps metal response element binding transcription factor 2, anticorps metal response element binding transcription factor 2 S homeolog, anticorps MTF2, anticorps mtf2.S, anticorps mtf2, anticorps Mtf2

Sujet: Synonyms:hPCl2, M96, MTF2, PCL2, Polycomb like protein 2, RP5 976O13.1 Background:Polycomb group(PcG) that specifically binds histone H3 trimethylated at 'Lys-36'(H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element(MRE) of MT1A gene promoter(By similarity).

Poids moléculaire: 60-61 kDa

ID gène: 22823

UniProt: Q9Y483

Pathways: Stem Cell Maintenance