MAP4K6 anticorps (AA 1-304)

N° du produit ABIN7116324

Cet anticorps anti-MAP4K6 est un anticorps Lapin Polyclonal détectant MAP4K6 dans WB, ELISA et IHC. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour MAP4K6 anticorps (AA 1-304) (ABIN7116324)

Antigène: MAP4K6 (MINK1) (Misshapen-Like Kinase 1 (MINK1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAP4K6 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-MAP4K6 anticorps

Épitope: AA 1-304

Fonction: MINK1 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène:

Immunogen sequence: 1-304aa

Immunogen: misshapen-like kinase 1(zebrafish)

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur MAP4K6

Antigène: MAP4K6 (MINK1) (Misshapen-Like Kinase 1 (MINK1))

Autre désignation: MINK1

Sujet:

Synonyms: Misshapen-like kinase 1|GCK family kinase MiNK|MAPK/ERK kinase kinase kinase 6 (MEK kinase kinase 6, MEKKK 6)|Misshapen/NIK-related kinase|Mitogen-activated protein kinase kinase kinase kinase 6|MINK1|B55|MAP4K6|MINK|YSK2|ZC3

Background: Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1. Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.

Poids moléculaire: 150 kDa

ID gène: 50488

UniProt: Q8N4C8

Pathways: Synaptic Membrane