MMS19 anticorps

N° du produit ABIN7116477

Cet anticorps anti-MMS19 est un anticorps Souris Monoclonal détectant MMS19 dans WB, ELISA, IF et IHC. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour MMS19 anticorps (ABIN7116477)

Antigène: MMS19 (MMS19 Nucleotide Excision Repair Homolog (MMS19))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MMS19 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC)

Clone: 6H1

Détail du produit anti-MMS19 anticorps

Fonction: MMS19 antibody

Purification: Protein A+G purification

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: MMS19 nucleotide excision repair homolog

Isotype: IgG2a

Information d'application

Indications d'application: WB: 1:1000-1:4000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur MMS19

Antigène: MMS19 (MMS19 Nucleotide Excision Repair Homolog (MMS19))

Autre désignation: MMS19

Sujet:

Synonyms: MMS19 nucleotide excision repair protein homolog (hMMS19)|MET18 homolog|MMS19-like protein|MMS19|MMS19L

Background: Key component of the cytosolic iron-sulfur protein assembly(CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair(NER) and RNA polymerase II(POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor(ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery.

Poids moléculaire: 103 kDa

ID gène: 64210

UniProt: Q96T76

Pathways: Nuclear Hormone Receptor Binding