Nth Endonuclease III-Like 1 (NTHL1) anticorps

N° du produit ABIN7116939

Cet anticorps anti- est un anticorps Lapin Polyclonal détectant dans WB, ELISA et IHC. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour Nth Endonuclease III-Like 1 (NTHL1) anticorps (ABIN7116939)

Antigène: Nth Endonuclease III-Like 1 (NTHL1)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit

Fonction: NTHL1 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: nth endonuclease III-like 1(E. coli)

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détail du antigène

Antigène: Nth Endonuclease III-Like 1 (NTHL1)

Autre désignation: NTHL1

Sujet:

Synonyms: Endonuclease III-like protein 1 (hNTH1)|Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase (DNA glycosylase/AP lyase)|NTHL1|NTH1|OCTS3

Background: Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic(AP) lyase function that catalyzes the first step in base excision repair(BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine(8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption.

Poids moléculaire: 34 kDa

ID gène: 4913

UniProt: P78549