OPTN anticorps

N° du produit ABIN7117124

L’anticorps Lapin Polyclonal anti-OPTN a été validé pour WB, IHC, ELISA, IP et IF. Il convient pour détecter OPTN dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour OPTN anticorps (ABIN7117124)

Antigène: OPTN (Optineurin (OPTN))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp OPTN est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP), Immunofluorescence (IF)

Détail du produit anti-OPTN anticorps

Fonction: OPTN antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: optineurin

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IP:1:500-1:1000, IHC: 1:50-1:500, IF: 1:10-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur OPTN

Antigène: OPTN (Optineurin (OPTN))

Autre désignation: OPTN

Sujet:

Synonyms: Optineurin|E3-14.7K-interacting protein (FIP-2)|Huntingtin yeast partner L|Huntingtin-interacting protein 7 (HIP-7)|Huntingtin-interacting protein L|NEMO-related protein|Optic neuropathy-inducing protein|Transcription factor IIIA-interacting protein (TFIIIA-IntP)|OPTN|FIP2|GLC1E|HIP7|HYPL|NRP

Background: Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin(HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as of transferrin receptor(TFRC/TfR), regulates Rab8 recruitnment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family, targets ubiquitin-coated bacteria(xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52. May constitute a cellular target for adenovirus E3 14.7, an inhibitor of TNF-alpha functions, thereby affecting cell death. This antibody recognises 66 and 70-74 kDa band, and the additional 70-74 kDa band due to phosphorylation.

Poids moléculaire: 66 kDa

ID gène: 10133

UniProt: Q96CV9

Pathways: M Phase