OTUD7B anticorps

N° du produit ABIN7117156

Cet anticorps Lapin Polyclonal détecte spécifiquement OTUD7B dans ELISA, WB, IHC et IP. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour OTUD7B anticorps (ABIN7117156)

Antigène: OTUD7B (OTU Domain Containing 7B (OTUD7B))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp OTUD7B est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Détail du produit anti-OTUD7B anticorps

Fonction: OTUD7B antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: OTU domain containing 7B

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur OTUD7B

Antigène: OTUD7B (OTU Domain Containing 7B (OTUD7B))

Autre désignation: OTUD7B

Sujet:

Synonyms: OTU domain-containing protein 7B|Cellular zinc finger anti-NF-kappa-B protein (Cezanne)|Zinc finger A20 domain-containing protein 1|Zinc finger protein Cezanne|OTUD7B|ZA20D1

Background: Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Mediates deubiquitination of EGFR. Has deubiquitinating activity toward 'Lys-11', 'Lys-48' or 'Lys-63'-linked polyubiquitin chains. In vitro, has preference for 'Lys-11'-linked polyubiquitin chains, however such data are unsure in vivo. Hydrolyzes both linear and branched forms of polyubiquitin.

Poids moléculaire: 100 kDa

ID gène: 56957

UniProt: Q6GQQ9