OTUD7B anticorps

N° du produit ABIN7117156

Détail du produit anti-OTUD7B anticorps

Antigène: OTUD7B (OTU Domain Containing 7B (OTUD7B))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp OTUD7B est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: OTU domain containing 7B

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur OTUD7B

Antigène: OTUD7B (OTU Domain Containing 7B (OTUD7B))

Autre désignation: OTUD7B (OTUD7B Produits)

Synonymes: anticorps OTUD7B, anticorps ZA20D1, anticorps za20d1, anticorps zgc:152772, anticorps cezanne, anticorps CEZANNE, anticorps 2900060B22Rik, anticorps 4930463P07Rik, anticorps AI462125, anticorps Trabid2, anticorps Za20d1, anticorps RGD1308111, anticorps OTU deubiquitinase 7B, anticorps OTU domain containing 7B, anticorps OTUD7B, anticorps otud7b, anticorps Otud7b

Sujet: Synonyms:ZA20D1 Background:Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Mediates deubiquitination of EGFR. Has deubiquitinating activity toward 'Lys-11', 'Lys-48' or 'Lys-63'-linked polyubiquitin chains. In vitro, has preference for 'Lys-11'-linked polyubiquitin chains, however such data are unsure in vivo. Hydrolyzes both linear and branched forms of polyubiquitin.

Poids moléculaire: 100 kDa

ID gène: 56957

UniProt: Q6GQQ9