OSBP anticorps

N° du produit ABIN7117171

Détail du produit anti-OSBP anticorps

Antigène: OSBP (Oxysterol Binding Protein (OSBP))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp OSBP est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: oxysterol binding protein

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur OSBP

Antigène: OSBP (Oxysterol Binding Protein (OSBP))

Autre désignation: OSBP (OSBP Produits)

Synonymes: anticorps CG6708, anticorps Dmel\\CG6708, anticorps OSBP-Dm, anticorps osbp, anticorps OSBP1, anticorps 1110018F06Rik, anticorps AW559088, anticorps mKIAA4220, anticorps Oxysterol binding protein, anticorps oxysterol binding protein, anticorps Osbp, anticorps OSBP

Sujet: Synonyms:OSBP1 Background:Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate(PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum(PubMed:24209621). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol(PubMed:15746430, PubMed:17428193). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly(PubMed:15746430). Regulates cholesterol efflux by decreasing ABCA1 stability(PubMed:18450749).

Poids moléculaire: 89 kDa

ID gène: 5007

UniProt: P22059