OSBPL3 anticorps (AA 370-520)

N° du produit ABIN7117176

Cet anticorps anti-OSBPL3 est un anticorps Lapin Polyclonal détectant OSBPL3 dans WB et ELISA. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour OSBPL3 anticorps (AA 370-520) (ABIN7117176)

Antigène: OSBPL3 (Oxysterol Binding Protein-Like 3 (OSBPL3))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp OSBPL3 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-OSBPL3 anticorps

Épitope: AA 370-520

Fonction: OSBPL3 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène:

Immunogen sequence: 370-520aa

Immunogen: oxysterol binding protein-like 3

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur OSBPL3

Antigène: OSBPL3 (Oxysterol Binding Protein-Like 3 (OSBPL3))

Autre désignation: OSBPL3

Sujet:

Synonyms: Oxysterol-binding protein-related protein 3 (ORP-3, OSBP-related protein 3)|OSBPL3|KIAA0704|ORP3|OSBP3

Background: Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum(ER) membranes(PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments(PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1(ITGB1) activation at the cell surface(PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology(PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion(PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3(PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol(PubMed:17428193).

Poids moléculaire: 101 kDa

ID gène: 26031

UniProt: Q9H4L5