PAN2 anticorps

N° du produit ABIN7117214

L’anticorps anti-PAN2 Polyclonal Lapin est utilisé pour la détection de PAN2 dans des échantillons de Humain, Souris et Rat. Il a été validé pour ELISA, WB et IHC.

Aperçu rapide pour PAN2 anticorps (ABIN7117214)

Antigène: PAN2 (PAN2 Poly(A) Specific Ribonuclease Subunit Homolog (PAN2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PAN2 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-PAN2 anticorps

Fonction: PAN2 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: PAN2 poly(A) specific ribonuclease subunit homolog

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur PAN2

Antigène: PAN2 (PAN2 Poly(A) Specific Ribonuclease Subunit Homolog (PAN2))

Autre désignation: PAN2

Sujet:

Synonyms: PAN2-PAN3 deadenylation complex catalytic subunit PAN2|Inactive ubiquitin carboxyl-terminal hydrolase 52|PAB1P-dependent poly(A)-specific ribonuclease|Poly(A)-nuclease deadenylation complex subunit 2 (PAN deadenylation complex subunit 2)|PAN2|KIAA0710|USP52

Background: Catalytic subunit of the poly(A)-nuclease(PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein(PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.

Poids moléculaire: 127 kDa

ID gène: 9924

UniProt: Q504Q3