PELI2 anticorps

N° du produit ABIN7117276

Cet anticorps Lapin Polyclonal détecte spécifiquement PELI2 dans WB, ELISA, IHC et IF. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour PELI2 anticorps (ABIN7117276)

Antigène: PELI2 (Pellino Homolog 2 (Drosophila) (PELI2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PELI2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-PELI2 anticorps

Fonction: PELI2 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: pellino homolog 2(Drosophila)

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur PELI2

Antigène: PELI2 (Pellino Homolog 2 (Drosophila) (PELI2))

Autre désignation: PELI2

Sujet:

Synonyms: E3 ubiquitin-protein ligase pellino homolog 2 (Pellino-2)|RING-type E3 ubiquitin transferase pellino homolog 2|PELI2

Background: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS-and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP(mitogen activated protein) kinase pathway leading to activation of ELK1.

Poids moléculaire: 45-50 kDa

ID gène: 57161

UniProt: Q9HAT8

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades