PHF2 anticorps

N° du produit ABIN7117376

L’anticorps Lapin Polyclonal anti-PHF2 a été validé pour WB, ELISA, IHC et IP. Il convient pour détecter PHF2 dans des échantillons de Humain.

Aperçu rapide pour PHF2 anticorps (ABIN7117376)

Antigène: PHF2 (PHD Finger Protein 2 (PHF2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PHF2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Détail du produit anti-PHF2 anticorps

Fonction: PHF2 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: PHD finger protein 2

Isotype: IgG

Information d'application

Indications d'application: WB: 1:200-1:1000, IP: 1:500-1:1000, IHC: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur PHF2

Antigène: PHF2 (PHD Finger Protein 2 (PHF2))

Autre désignation: PHF2

Sujet:

Synonyms: Lysine-specific demethylase PHF2|GRC5|PHD finger protein 2|PHF2|CENP-35|KIAA0662

Background: Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3(H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3(H3K4me3) at rDNA promoters and promotes expression of rDNA.

Poids moléculaire: 100 kDa, 150 kDa

ID gène: 5253

UniProt: O75151