PHAX anticorps

N° du produit ABIN7117517

L’anticorps Lapin Polyclonal anti-PHAX a été validé pour WB et ELISA. Il convient pour détecter PHAX dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour PHAX anticorps (ABIN7117517)

Antigène: PHAX (phosphorylated Adaptor For RNA Export (PHAX))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PHAX est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-PHAX anticorps

Fonction: PHAX antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: phosphorylated adaptor for RNA export

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur PHAX

Antigène: PHAX (phosphorylated Adaptor For RNA Export (PHAX))

Autre désignation: PHAX

Sujet:

Synonyms: Phosphorylated adapter RNA export protein|RNA U small nuclear RNA export adapter protein|PHAX|RNUXA

Background: A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex(CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs(snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner(By similarity). Plays also a role in the biogenesis of U3 small nucleolar RNA(snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated(TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA.

Poids moléculaire: 55 kDa

ID gène: 51808

UniProt: Q9H814

Pathways: Ribonucleoprotein Complex Subunit Organization