PIWIL1 anticorps

N° du produit ABIN7117540

Détail du produit anti-PIWIL1 anticorps

Antigène: PIWIL1 (Piwi-Like 1 (PIWIL1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PIWIL1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP)

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: piwi-like 1(Drosophila)

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur PIWIL1

Antigène: PIWIL1 (Piwi-Like 1 (PIWIL1))

Autre désignation: PIWIL1 (PIWIL1 Produits)

Synonymes: anticorps ziwi, anticorps PIWI, anticorps HIWI, anticorps MIWI, anticorps piwi like RNA-mediated gene silencing 1, anticorps PIWI-like protein 1, anticorps putative PIWI-like protein 1, anticorps putative argonaut-like protein, anticorps piwi-like RNA-mediated gene silencing 1, anticorps PIWIL1, anticorps Tb10.70.5520, anticorps LINJ_21_0470, anticorps LBRM_21_0470, anticorps piwil1, anticorps Piwil1

Sujet: Synonyms:HIWI Background:Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Probable component of some RISC complex, which mediates RNA cleavage and translational silencing. Also plays a role in the formation of chromatoid bodies and is required for some miRNAs stability(By similarity). Isoform 3 may be a negative developmental regulator(PubMed:12037681, PubMed:16287078).

Poids moléculaire: 85-95 kDa

ID gène: 9271

UniProt: Q96J94