POLR3G anticorps

N° du produit ABIN7117683

Cet anticorps anti-POLR3G est un anticorps Polyclonal produit chez le Lapin, détectant POLR3G dans WB et ELISA. Convient pour Humain.

Aperçu rapide pour POLR3G anticorps (ABIN7117683)

Antigène: POLR3G (Polymerase (RNA) III (DNA Directed) Polypeptide G (32kD) (POLR3G))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp POLR3G est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-POLR3G anticorps

Fonction: POLR3G antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: polymerase(RNA) III(DNA directed) polypeptide G(32kD)

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur POLR3G

Antigène: POLR3G (Polymerase (RNA) III (DNA Directed) Polypeptide G (32kD) (POLR3G))

Autre désignation: POLR3G

Sujet:

Synonyms: DNA-directed RNA polymerase III subunit RPC7 (RNA polymerase III subunit C7)|DNA-directed RNA polymerase III subunit G|RNA polymerase III 32 kDa apha subunit (RPC32-alpha)|RNA polymerase III 32 kDa subunit (RPC32)|POLR3G

Background: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the RPC3/POLR3C-RPC6/POLR3F-RPC7/POLR3G subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs(EBERs) induce type I interferon and NF-Kappa-B through the RIG-I pathway.

Poids moléculaire: 26-30 kDa

ID gène: 10622

UniProt: O15318