FIP200 anticorps

N° du produit ABIN7118327

L’anticorps Lapin Polyclonal anti-FIP200 a été validé pour WB, ELISA, IHC, IF et IP. Il convient pour détecter FIP200 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour FIP200 anticorps (ABIN7118327)

Antigène: FIP200 (RB1CC1) (RB1-Inducible Coiled-Coil 1 (RB1CC1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FIP200 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Détail du produit anti-FIP200 anticorps

Fonction: RB1CC1 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène:

Immunogen sequence: 1480-1594

Immunogen: RB1-inducible coiled-coil 1

Isotype: IgG

Information d'application

Indications d'application: WB: 1:1000-1:6000, IP:1:500-1:1000, IHC: 1:20-1:200, IF: 1:10-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur FIP200

Antigène: FIP200 (RB1CC1) (RB1-Inducible Coiled-Coil 1 (RB1CC1))

Autre désignation: RB1CC1

Sujet:

Synonyms: RB1-inducible coiled-coil protein 1|FAK family kinase-interacting protein of 200 kDa (FIP200)|RB1CC1|KIAA0203|RBICC

Background: Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111. Involved in autophagy. Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1. Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole(SCV) duting S.typhimurium infection and subsequent xenophagy. Autophagy positively regulates repair of DNA damage induced by ionizing radiation and negatively regulates apoptosis. Plays an indispensible role in fetal hematopoiesis and in the regulation of neuronal homeostasis(By similarity). Implicated in the regulation of RB1 expression. Functions as a DNA-binding transcription factor. Is a potent regulator of the RB1 pathway and a mediator that plays a crucial role in muscular differentiation. Expression is, thus, a prerequisite for myogenic differentiation. Inhibits PTK2/FAK1 and PTK2B/PYK2 activity and activation of downstream signaling pathways.

Poids moléculaire: 200 kDa

ID gène: 9821

UniProt: Q8TDY2

Pathways: Regulation of Cell Size, Autophagy