RRP8 anticorps

N° du produit ABIN7118623

Cet anticorps Lapin Polyclonal détecte spécifiquement RRP8 dans WB, ELISA, IHC et IF. Il présente une réactivité envers Humain, Rat et Souris.

Aperçu rapide pour RRP8 anticorps (ABIN7118623)

Antigène: RRP8 (Ribosomal RNA Processing 8 (RRP8))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RRP8 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-RRP8 anticorps

Fonction: RRP8 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: ribosomal RNA processing 8, methyltransferase, homolog(yeast)

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur RRP8

Antigène: RRP8 (Ribosomal RNA Processing 8 (RRP8))

Autre désignation: RRP8

Sujet:

Synonyms: Ribosomal RNA-processing protein 8|Cerebral protein 1|Nucleomethylin|RRP8|KIAA0409|NML

Background: Essential component of the eNoSC(energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9'(H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.

Poids moléculaire: 51 kDa

ID gène: 23378

UniProt: O43159