RRP8 anticorps

N° du produit ABIN7118623

Détail du produit anti-RRP8 anticorps

Antigène: RRP8 (Ribosomal RNA Processing 8 (RRP8))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RRP8 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: ribosomal RNA processing 8, methyltransferase, homolog(yeast)

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur RRP8

Antigène: RRP8 (Ribosomal RNA Processing 8 (RRP8))

Autre désignation: RRP8 (RRP8 Produits)

Synonymes: anticorps KIAA0409, anticorps 1500003O22Rik, anticorps 2900001K19Rik, anticorps AW538116, anticorps RGD1308302, anticorps ribosomal RNA processing 8, anticorps ribosomal RNA processing 8, methyltransferase, homolog (yeast), anticorps RRP8, anticorps Rrp8

Sujet: Synonyms:KIAA0409, NML Background:Essential component of the eNoSC(energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9'(H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.

Poids moléculaire: 51 kDa

ID gène: 23378

UniProt: O43159