RNF4 anticorps

N° du produit ABIN7118657

L’anticorps Lapin Polyclonal anti-RNF4 a été validé pour ELISA et IP. Il convient pour détecter RNF4 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour RNF4 anticorps (ABIN7118657)

Antigène: RNF4 (Ring Finger Protein 4 (RNF4))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RNF4 est non-conjugé

Application: ELISA, Immunoprecipitation (IP)

Détail du produit anti-RNF4 anticorps

Fonction: RNF4 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: ring finger protein 4

Isotype: IgG

Information d'application

Indications d'application: IP: 1:200-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur RNF4

Antigène: RNF4 (Ring Finger Protein 4 (RNF4))

Autre désignation: RNF4

Sujet:

Synonyms: E3 ubiquitin-protein ligase RNF4|RING finger protein 4|Small nuclear ring finger protein (Protein SNURF)|RNF4|SNURF

Background: E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'-and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation.

ID gène: 6047

UniProt: P78317

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway