RLIM anticorps

N° du produit ABIN7118663

L’anticorps Lapin Polyclonal anti-RLIM a été validé pour WB, ELISA et IP. Il convient pour détecter RLIM dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour RLIM anticorps (ABIN7118663)

Antigène: RLIM (Ring Finger Protein, LIM Domain Interacting (RLIM))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RLIM est non-conjugé

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Détail du produit anti-RLIM anticorps

Fonction: RLIM antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: ring finger protein, LIM domain interacting

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IP: 1:200-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur RLIM

Antigène: RLIM (Ring Finger Protein, LIM Domain Interacting (RLIM))

Autre désignation: RLIM

Sujet:

Synonyms: E3 ubiquitin-protein ligase RLIM|LIM domain-interacting RING finger protein|RING finger LIM domain-binding protein (R-LIM)|RING finger protein 12|RING-type E3 ubiquitin transferase RLIM|Renal carcinoma antigen NY-REN-43|RLIM|RNF12

Background: E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals.

Poids moléculaire: 75 kDa

ID gène: 51132

UniProt: Q9NVW2