RBM25 anticorps

N° du produit ABIN7118681

L’anticorps Lapin Polyclonal anti-RBM25 a été validé pour WB, ELISA et IHC. Il convient pour détecter RBM25 dans des échantillons de Souris et Humain.

Aperçu rapide pour RBM25 anticorps (ABIN7118681)

Antigène: RBM25 (RNA Binding Motif Protein 25 (RBM25))

Reactivité: Souris, Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RBM25 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-RBM25 anticorps

Fonction: RBM25 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: RNA binding motif protein 25

Isotype: IgG

Information d'application

Indications d'application: WB: 1:200-1:2000, IP: 1:200-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur RBM25

Antigène: RBM25 (RNA Binding Motif Protein 25 (RBM25))

Autre désignation: RBM25

Sujet:

Synonyms: RNA-binding protein 25|Arg/Glu/Asp-rich protein of 120 kDa (RED120)|Protein S164|RNA-binding motif protein 25|RNA-binding region-containing protein 7|RBM25|RNPC7

Background: RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site(5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure.

Poids moléculaire: 110-120 kDa

ID gène: 58517

UniProt: P49756