SHARPIN anticorps (AA 1-194)

N° du produit ABIN7119030

Cet anticorps anti-SHARPIN est un anticorps Lapin Polyclonal détectant SHARPIN dans WB, ELISA et IHC. Adapté pour Humain, Rat et Souris.

Aperçu rapide pour SHARPIN anticorps (AA 1-194) (ABIN7119030)

Antigène: SHARPIN (SHANK-Associated RH Domain Interacting Protein (SHARPIN))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SHARPIN est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-SHARPIN anticorps

Épitope: AA 1-194

Fonction: SHARPIN antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène:

Immunogen sequence: 1-194aa

Immunogen: SHANK-associated RH domain interactor

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur SHARPIN

Antigène: SHARPIN (SHANK-Associated RH Domain Interacting Protein (SHARPIN))

Autre désignation: SHARPIN

Sujet:

Synonyms: Sharpin|Shank-associated RH domain-interacting protein|Shank-interacting protein-like 1 (hSIPL1)|SHARPIN|SIPL1

Background: Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex(TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.

Poids moléculaire: 40 kDa

ID gène: 81858

UniProt: Q9H0F6