SIX2 anticorps

N° du produit ABIN7119117

Cet anticorps anti-SIX2 est un anticorps Lapin Polyclonal détectant SIX2 dans WB, ELISA, IF et IP. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour SIX2 anticorps (ABIN7119117)

Antigène: SIX2 (SIX Homeobox 2 (SIX2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SIX2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP)

Détail du produit anti-SIX2 anticorps

Fonction: SIX2 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: SIX homeobox 2

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:1000, IP: 1:500-1:1000, IF: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur SIX2

Antigène: SIX2 (SIX Homeobox 2 (SIX2))

Autre désignation: SIX2

Sujet:

Synonyms: Homeobox protein SIX2|Sine oculis homeobox homolog 2|SIX2

Background: Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach. During kidney development, maintains cap mesenchyme multipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud and cooperates with WNT9B to promote renewing progenitor cells proliferation. Acts through its interaction with TCF7L2 and OSR1 in a canonical Wnt signaling independent manner preventing transcription of differentiation genes in cap mesenchyme such as WNT4. Also acts independently of OSR1 to activate expression of many cap mesenchyme genes, including itself, GDNF and OSR1. During craniofacial development plays a role in growth and elongation of the cranial base through regulation of chondrocyte differentiation. During stomach organogenesis, controls pyloric sphincter formation and mucosal growth through regulation of a gene network including NKX2-5, BMPR1B, BMP4, SOX9 and GREM1. During branchial arch development, acts to mediate HOXA2 control over the insulin-like growth factor pathway. Also may be involved in limb tendon and ligament development(By similarity). Plays a role in cell proliferation and migration.

Poids moléculaire: 35 kDa

ID gène: 10736

UniProt: Q9NPC8

Pathways: Protein targeting to Nucleus