Sorting Nexin 3 anticorps

N° du produit ABIN7119361

Cet anticorps Lapin Polyclonal détecte spécifiquement Sorting Nexin 3 dans ELISA, WB et IF. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour Sorting Nexin 3 anticorps (ABIN7119361)

Antigène: Sorting Nexin 3 (SNX3)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Sorting Nexin 3 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-Sorting Nexin 3 anticorps

Fonction: SNX3 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: sorting nexin 3

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IF: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur Sorting Nexin 3

Antigène: Sorting Nexin 3 (SNX3)

Autre désignation: SNX3

Sujet:

Synonyms: Sorting nexin-3|Protein SDP3|SNX3

Background: Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate(PtdIns(P3)). Also can bind phosphatidylinositol 4-phosphate(PtdIns(P4)), phosphatidylinositol 5-phosphate(PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate(PtdIns(3,5)P2)(By similarity). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex(CSC/VPS). May in part act as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway(PubMed:21725319, PubMed:24344282). Promotes stability and cell surface expression of epithelial sodium channel(ENAC) subunits SCNN1A and SCNN1G(By similarity). Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes(PubMed:23237080). Involved in iron homeostasis through regulation of endocytic recycling of the transferrin receptor TFRC presumably by delivering the tranferrin:transferrin receptor complex to recycling endosomes, the function may involve the CSC retromer subcomplex(By similarity). In the case of Salmonella enterica infection plays arole in maturation of the Salmonella-containing vacuole(SCV) and promotes recruitment of LAMP1 to SCVs(PubMed:20482551).

Poids moléculaire: 16-20 kDa

ID gène: 8724

UniProt: O60493