SNX5 anticorps

N° du produit ABIN7119364

Détail du produit anti-SNX5 anticorps

Antigène: SNX5 (Sorting Nexin 5 (SNX5))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SNX5 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: sorting nexin 5

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur SNX5

Antigène: SNX5 (Sorting Nexin 5 (SNX5))

Autre désignation: SNX5 (SNX5 Produits)

Synonymes: anticorps 0910001N05Rik, anticorps 1810032P22Rik, anticorps AU019504, anticorps D2Ertd52e, anticorps id:ibd5091, anticorps wu:fa66c10, anticorps wu:fi28h04, anticorps zgc:55769, anticorps SNX5, anticorps snx5, anticorps sorting nexin 5, anticorps sorting nexin 5 S homeolog, anticorps SNX5, anticorps Snx5, anticorps snx5.S, anticorps snx5

Sujet: Synonyms: Background:Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate(PtdIns(3P)) or phosphatidylinositol 3,4-bisphosphate(PtdIns(3,4)P2)(PubMed:15561769). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network(TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier(ETC)(Probable). Does not have in vitro vesicle-to-membrane remodeling activity(PubMed:23085988). Involved in retrograde transport of lysosomal enzyme receptor IGF2R(PubMed:17148574, PubMed:18596235). May function as link between endosomal transport vesicles and dynactin(Probable). Plays a role in the internalization of EGFR after EGF stimulation(Probable). Involved in EGFR endosomal sorting and degradation, the function involves PIP5K1C isoform 3 and is retromer-independent(PubMed:23602387). Together with PIP5K1C isoform 3 facilitates HGS interaction with ubiquitinated EGFR, which initiates EGFR sorting to intraluminal vesicles(ILVs) of the multivesicular body for subsequent lysosomal degradation(Probable). Involved in E-cadherin sorting and degradation, inhibits PIP5K1C isoform 3-mediated E-cadherin degradation(PubMed:24610942). Plays a role in macropinocytosis(PubMed:18854019, PubMed:21048941).

Poids moléculaire: 47 kDa

ID gène: 27131

UniProt: Q9Y5X3