SPOP-B anticorps (AA 4-175)

N° du produit ABIN7119381

Cet anticorps anti-SPOP-B est un anticorps Lapin Polyclonal détectant SPOP-B dans WB, ELISA, IHC et IP. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour SPOP-B anticorps (AA 4-175) (ABIN7119381)

Antigène: SPOP-B (Speckle-Type POZ Protein (SPOP-B))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SPOP-B est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Détail du produit anti-SPOP-B anticorps

Épitope: AA 4-175

Fonction: SPOP antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène:

Immunogen sequence: 4-175aa

Immunogen: speckle-type POZ protein

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IHC: 1:50-1:500, IP : 1:500-1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur SPOP-B

Antigène: SPOP-B (Speckle-Type POZ Protein (SPOP-B))

Autre désignation: SPOP

Sujet:

Synonyms: Speckle-type POZ protein|HIB homolog 1|Roadkill homolog 1|SPOP

Background: Component of a cullin-RING-based BCR(BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of H2AFY and BMI1, this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING-based BCR(BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOP has higher ubiquitin ligase activity than the complex that contains the heterodimer formed by SPOP and SPOPL.

Poids moléculaire: 42 kDa

ID gène: 8405

UniProt: O43791