SMC5 anticorps

N° du produit ABIN7119560

L’anticorps Lapin Polyclonal anti-SMC5 a été validé pour WB et ELISA. Il convient pour détecter SMC5 dans des échantillons de Humain, Rat et Souris.

Aperçu rapide pour SMC5 anticorps (ABIN7119560)

Antigène: SMC5 (Structural Maintenance of Chromosomes 5 (SMC5))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SMC5 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-SMC5 anticorps

Fonction: SMC5 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: structural maintenance of chromosomes 5

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur SMC5

Antigène: SMC5 (Structural Maintenance of Chromosomes 5 (SMC5))

Autre désignation: SMC5

Sujet:

Synonyms: Structural maintenance of chromosomes protein 5 (SMC protein 5, SMC-5, hSMC5)|SMC5|KIAA0594|SMC5L1

Background: Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT(alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex(telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies(APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression, the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome(PubMed:26983541).

Poids moléculaire: 120-130 kDa

ID gène: 23137

UniProt: Q8IY18