Spt6 anticorps

N° du produit ABIN7119612

Cet anticorps anti-Spt6 est un anticorps Lapin Polyclonal détectant Spt6 dans WB, IP et ELISA. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour Spt6 anticorps (ABIN7119612)

Antigène: Spt6 (SUPT6H) (Suppressor of Ty 6 Homolog (SUPT6H))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Spt6 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), ELISA

Détail du produit anti-Spt6 anticorps

Fonction: SUPT6H antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: suppressor of Ty 6 homolog

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IP: 1:200-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur Spt6

Antigène: Spt6 (SUPT6H) (Suppressor of Ty 6 Homolog (SUPT6H))

Autre désignation: SUPT6H

Sujet:

Synonyms: Transcription elongation factor SPT6 (hSPT6)|Histone chaperone suppressor of Ty6|Tat-cotransactivator 2 protein (Tat-CT2 protein)|SUPT6H|KIAA0162|SPT6H

Background: Transcription elongation factor which binds histone H3 and plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II(RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain(CTD) of the RNAPII subunit RPB1(POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors(ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes(such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase(AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A.

Poids moléculaire: 230 kDa

ID gène: 9913

UniProt: Q7KZ85

Pathways: Regulation of Leukocyte Mediated Immunity, Regulation of Muscle Cell Differentiation, Production of Molecular Mediator of Immune Response