SS18L1 anticorps (AA 47-396)

N° du produit ABIN7119693

Cet anticorps anti-SS18L1 Monoclonal Souris (Clone 7A7) (ABIN7119693) détecte spécifiquement SS18L1 dans WB et ELISA. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour SS18L1 anticorps (AA 47-396) (ABIN7119693)

Antigène: SS18L1 (Synovial Sarcoma Translocation Gene On Chromosome 18-Like 1 (SS18L1))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SS18L1 est non-conjugé

Application: Western Blotting (WB), ELISA

Clone: 7A7

Détail du produit anti-SS18L1 anticorps

Épitope: AA 47-396

Fonction: SS18L1 antibody

Purification: Protein A+G purification

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène:

Immunogen sequence: 47-396aa

Immunogen: synovial sarcoma translocation gene on chromosome 18-like 1

Isotype: IgG1

Information d'application

Indications d'application: WB: 1:1000-1:6000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur SS18L1

Antigène: SS18L1 (Synovial Sarcoma Translocation Gene On Chromosome 18-Like 1 (SS18L1))

Autre désignation: SS18L1

Sujet:

Synonyms: Calcium-responsive transactivator|SS18-like protein 1|SYT homolog 1|SS18L1|CREST|KIAA0693

Background: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein(CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP(By similarity).

Poids moléculaire: 50 kDa

ID gène: 26039

UniProt: O75177