TBC1D5 anticorps

N° du produit ABIN7119805

Cet anticorps Lapin Polyclonal détecte spécifiquement TBC1D5 dans WB, ELISA, IP et IHC. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour TBC1D5 anticorps (ABIN7119805)

Antigène: TBC1D5 (TBC1 Domain Family, Member 5 (TBC1D5))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TBC1D5 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunohistochemistry (IHC)

Détail du produit anti-TBC1D5 anticorps

Fonction: TBC1D5 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: TBC1 domain family, member 5

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2400, IP: 1:200-1:1000 , IHC: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur TBC1D5

Antigène: TBC1D5 (TBC1 Domain Family, Member 5 (TBC1D5))

Autre désignation: TBC1D5

Sujet:

Synonyms: TBC1 domain family member 5|TBC1D5|KIAA0210

Background: May act as a GTPase-activating protein(GAP) for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol, at least retromer displacement seems to require its catalytic activity(PubMed:19531583, PubMed:20923837). Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network(TGN), the function seems to require its catalytic activity. Involved in regulation of autophagy(PubMed:22354992). May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes(PubMed:24603492).

Poids moléculaire: 89 kDa

ID gène: 9779

UniProt: Q92609