TEAD2 anticorps

N° du produit ABIN7119811

Cet anticorps Lapin Polyclonal détecte spécifiquement TEAD2 dans ELISA et WB. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour TEAD2 anticorps (ABIN7119811)

Antigène: TEAD2 (TEA Domain Family Member 2 (TEAD2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TEAD2 est non-conjugé

Application: ELISA, Western Blotting (WB)

Détail du produit anti-TEAD2 anticorps

Fonction: TEAD2 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: TEA domain family member 2

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur TEAD2

Antigène: TEAD2 (TEA Domain Family Member 2 (TEAD2))

Autre désignation: TEAD2

Sujet:

Synonyms: Transcriptional enhancer factor TEF-4|TEA domain family member 2 (TEAD-2)|TEAD2|TEF4

Background: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition(EMT) induction. Binds to the SPH and GT-IIC 'enhansons'(5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.

Poids moléculaire: 55-65 kDa

ID gène: 8463

UniProt: Q15562

Pathways: Regulation of Lipid Metabolism by PPARalpha, Tube Formation