TSPAN12 anticorps

N° du produit ABIN7119860

L’anticorps Lapin Polyclonal anti-TSPAN12 a été validé pour WB et ELISA. Il convient pour détecter TSPAN12 dans des échantillons de Humain, Rat et Souris.

Aperçu rapide pour TSPAN12 anticorps (ABIN7119860)

Antigène: TSPAN12 (Tetraspanin 12 (TSPAN12))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TSPAN12 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-TSPAN12 anticorps

Fonction: TSPAN12 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: tetraspanin 12

Isotype: IgG

Information d'application

Indications d'application: WB: 1:200-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur TSPAN12

Antigène: TSPAN12 (Tetraspanin 12 (TSPAN12))

Autre désignation: TSPAN12

Sujet:

Synonyms: Tetraspanin-12 (Tspan-12)|Tetraspan NET-2|Transmembrane 4 superfamily member 12|TSPAN12|NET2|TM4SF12

Background: Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin(NDP) signal transduction. Acts in concert with norrin(NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin(CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin(NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin(CTNNB1)(By similarity). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein(APP). Activates MMP14/MT1-MMP-dependent cleavage activity.

Poids moléculaire: 28 kDa

ID gène: 23554

UniProt: O95859