TRAIP anticorps (AA 1-204)

N° du produit ABIN7120031

L’anticorps Lapin Polyclonal anti-TRAIP a été validé pour ELISA, IHC, WB et IF. Il convient pour détecter TRAIP dans des échantillons de Humain et Souris.

Aperçu rapide pour TRAIP anticorps (AA 1-204) (ABIN7120031)

Antigène: TRAIP (TRAF Interacting Protein (TRAIP))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRAIP est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-TRAIP anticorps

Épitope: AA 1-204

Fonction: TRAIP antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène:

Immunogen sequence: 1-204aa

Immunogen: TRAF interacting protein

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:10-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur TRAIP

Antigène: TRAIP (TRAF Interacting Protein (TRAIP))

Autre désignation: TRAIP

Sujet:

Synonyms: E3 ubiquitin-protein ligase TRAIP|RING finger protein 206|TRAF-interacting protein|TRAIP|RNF206|TRIP

Background: E3 ubiquitin ligase acting as a negative regulator of innate immune signaling. Inhibits activation of NF-kappa-B mediated by TNF. Negatively regulates TLR3/4-and RIG-I-mediated IRF3 activation and subsequent IFNB1 production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation(By similarity)(PubMed:22945920). Involved in response to genotoxic lesions during genome replication. Promotes H2AX and RPA2 phosphorylation after replication-associated DNA damage and assists fork progression at UV-induced replication-blocking lesions during S phase(PubMed:26595769). Has also been proposed to play a role in promoting translesion synthesis by mediating the assembly of 'Lys-63'-linked poly-ubiquitin chains on the Y-family polymerase POLN in order to facilitate bypass of DNA lesions and preserve genomic integrity(PubMed:24553286). The function in translesion synthesis is controversial(PubMed:26595769).

Poids moléculaire: 53 kDa

ID gène: 10293

UniProt: Q9BWF2