TRIM25 anticorps

N° du produit ABIN7120280

L’anticorps Lapin Polyclonal anti-TRIM25 a été validé pour WB, ELISA, IF et IP. Il convient pour détecter TRIM25 dans des échantillons de Humain et Souris.

Aperçu rapide pour TRIM25 anticorps (ABIN7120280)

Antigène: TRIM25 (Tripartite Motif Containing 25 (TRIM25))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRIM25 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP)

Détail du produit anti-TRIM25 anticorps

Fonction: TRIM25 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: tripartite motif-containing 25

Isotype: IgG

Information d'application

Indications d'application: WB: 1:200-1:2000, IP: 1:200-1:2000, IF: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur TRIM25

Antigène: TRIM25 (Tripartite Motif Containing 25 (TRIM25))

Autre désignation: TRIM25

Sujet:

Synonyms: E3 ubiquitin/ISG15 ligase TRIM25|Estrogen-responsive finger protein|RING finger protein 147|RING-type E3 ubiquitin transferase|RING-type E3 ubiquitin transferase TRIM25|Tripartite motif-containing protein 25|Ubiquitin/ISG15-conjugating enzyme TRIM25|Zinc finger protein 147|TRIM25|EFP|RNF147|ZNF147

Background: Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma(SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs. Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3(PubMed:22452784).

Poids moléculaire: 71 kDa

ID gène: 7706

UniProt: Q14258