USP15 anticorps

N° du produit ABIN7120499

L’anticorps Lapin Polyclonal anti-USP15 a été validé pour WB, ELISA et IP. Il convient pour détecter USP15 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour USP15 anticorps (ABIN7120499)

Antigène: USP15 (Ubiquitin Specific Peptidase 15 (USP15))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp USP15 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Détail du produit anti-USP15 anticorps

Fonction: USP15 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: ubiquitin specific peptidase 15

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:5000, IP: 1:500-1:5000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur USP15

Antigène: USP15 (Ubiquitin Specific Peptidase 15 (USP15))

Autre désignation: USP15

Sujet:

Synonyms: Ubiquitin carboxyl-terminal hydrolase 15|Deubiquitinating enzyme 15|Ubiquitin thioesterase 15|Ubiquitin-specific-processing protease 15|Unph-2|Unph4|USP15|KIAA0529

Background: Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs(SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes(PubMed:21947082). According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal(PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates as well as 'Lys-48'-linked polyubiquitin chains, protecting them against proteasomal degradation. May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B(PubMed:24526689). Acts as an associated component of COP9 signalosome complex(CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP. Protects APC and human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway.

Poids moléculaire: 112 kDa

ID gène: 9958

UniProt: Q9Y4E8