ULBP1 anticorps

N° du produit ABIN7120610

L’anticorps Lapin Polyclonal anti-ULBP1 a été validé pour ELISA, WB et IHC. Il convient pour détecter ULBP1 dans des échantillons de Humain et Souris.

Aperçu rapide pour ULBP1 anticorps (ABIN7120610)

Antigène: ULBP1 (UL16 Binding Protein 1 (ULBP1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ULBP1 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-ULBP1 anticorps

Fonction: ULBP1 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: UL16 binding protein 1

Isotype: IgG

Information d'application

Indications d'application: WB: 1:200-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur ULBP1

Antigène: ULBP1 (UL16 Binding Protein 1 (ULBP1))

Autre désignation: ULBP1

Sujet:

Synonyms: UL16-binding protein 1|ALCAN-beta|NKG2D ligand 1 (N2DL-1, NKG2DL1)|Retinoic acid early transcript 1I|ULBP1|N2DL1|RAET1I

Background: Ligand for the KLRK1/NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.

Poids moléculaire: 30 kDa, 37 kDa

ID gène: 80329

UniProt: Q9BZM6

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process