MAF anticorps

N° du produit ABIN7120681

Détail du produit anti-MAF anticorps

Antigène: MAF (V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (Avian) (MAF))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAF est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: v-maf musculoaponeurotic fibrosarcoma oncogene homolog

Isotype: IgG

Information d'application

Indications d'application: WB: 1:200-1:2000, IP: 1:200-1:2000, IHC: 1:20-1:200, IF: 1:50-1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur MAF

Antigène: MAF (V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (Avian) (MAF))

Autre désignation: MAF (MAF Produits)

Synonymes: anticorps MAF, anticorps DKFZp459D1731, anticorps 2810401A20Rik, anticorps A230108G15Rik, anticorps AW047063, anticorps c-maf, anticorps CCA4, anticorps c-MAF, anticorps Maf2, anticorps cMaf, anticorps Z-cmaf, anticorps c-Maf, anticorps fl13d12, anticorps wu:fl13d12, anticorps C-Maf, anticorps MAF bZIP transcription factor, anticorps v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian), anticorps avian musculoaponeurotic fibrosarcoma oncogene homolog, anticorps v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog a (paralog a), anticorps MAF, anticorps Maf, anticorps mafa

Sujet: Synonyms:c MAF, cMAF, MAF, Proto oncogene c Maf, Transcription factor Maf Background:Acts as a transcriptional activator or repressor. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2(Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter. Binds to the T-MARE(Maf response element) sites of lens-specific alpha-and beta-crystallin gene promoters. Binds element G1 on the glucagon promoter. Binds an AT-rich region adjacent to the TGC motif(atypical Maf response element) in the CD13 proximal promoter in endothelial cells(By similarity). When overexpressed, represses anti-oxidant response element(ARE)-mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters.

Poids moléculaire: 50 kDa

ID gène: 4094

UniProt: O75444